Abstract
A 76-year-old woman, with no pathological history of interest, presented with long-standing ulcers on the lower limbs. On the left lower extremity she presented a large ulcer, 23 years old, of multifactorial cause, with irregular borders, abundant exudate and wound bed occupied by a fibrinous tissue that bled easily and that, distally, had grown to exceed the edges of the wound. A biopsy confirmed malignancy in the form of a Marjolin's ulcer (high-grade infil-trating cutaneous squamous cell carcinoma), which required an infracondylar amputation of the limb. Chronic wounds that do not heal despite adequate treatment or that present clinical signs and/or atypical locations should be biopsied as soon as possible. Once the diagnosis of malignancy is confirmed, the approach should be multidisciplinary.
References
Baldursson B, Sigurgeirsson B, Lindelöf B. “Venous leg ulcers and squamous cell carcinoma: a largescale epidemiological study”. Br J Dermatol. 1995 Oct;133(4):571-4. doi: 10.1111/j.1365-2133.1995.tb02707.x.
Bazalioski D, Przybek-Mita J, Baraoska B, Więch P. Úlcera de Marjolin en heridas crónicas: revisión de la literatura disponible. Contemp Oncol. 2017; 21 (3):197-202.
Conde Montero E. Ante una úlcera cutánea, ¿Cuándo debemos sospechar una causa tumoral? [Internet]. 2015. Cuando una herida en la piel no se cierra. [Citado el 12/05/2023]. Disponible en:https://www.elenaconde.
com/ante-una-ulceracutanea-cuando-debemos-sospechar-una-causatumoral/.
Gale SS, Lurie F, Treadwell T, Vazquez J, Carman T, Partsch H, Alvarez O, Langemo D, Posthauer ME, Cheney M, Wilkin MM, Bursztynski M. DOMINATE Wounds. Wounds. 2014; 26 (1):1-12.
Martínez-Ramos D, Villalba-Munera V, Molina-Martínez J, Salvador-Sanchís JL. Úlcera de Marjolin sobre una úlcera venosa crónica: revisión de la bibliografía y comunicación de un caso. Angiología. 2006; 58 (1): 63-6. Disponible en: https://jorgemolina.es/wp-content/uploads/2019/11/Ulcera-Angiologia-2006.pdf
Shah M, Crane JS. Marjolin Ulcer. [Actualizado 2023 Mar 20]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK532
Toussaint F, Erdmann M, Berking C, Erfurt-Berge C. Malignant Tumours Presenting as Chronic Leg or Foot Ulcers. J Clin Med. 2021; 10(11):2251. doi:10.3390/jcm10112251. Disponible en: https://www.mdpi.com/2077-0383/
/11/2251
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