Keywords
How to Cite
Abstract
There is increasing evidence to suggest that wound healing in chronic vascular and diabetic foot ulcers is dependent on growth factor and that the therapeutic delivery of these growth factors to topical wounds has the potential ability to accelerate healing. of wounds together with conventional wound care
A prospective quasi-experimental study has been designed and planned with the objective of evaluating the safety and efficacy of platelet-rich autologous plasma gel for the treatment of vascular ulcers of the lower limbs and diabetic foot with delayed healing. Through this pilot study, the viability of said study and the suitability of the action protocol, the variables collected and the measuring instrument have been assessed.
This pilot study was carried out between September 2018 and March 2020 at the Vascular Surgery Service of the Reina Sofía University Hospital in Córdoba. Participated patients with vascular or diabetic foot ulcers who had delayed healing process and to whom PRP was applied
Four patients with a mean age of 62.25 years participated in the pilot study. 100% were men with diabetic foot injuries. 50% had associated peripheral artery disease, with a mean healing delay of 17 months with an interval of 12-20. The mean healing time of the ulcers was 7.6 weeks. In no case were any adverse effects related to the application of PRP detected.
Based on these preliminary results, the application of PRP to the bed of non-healing vascular and diabetic foot wounds is a safe and effective therapeutic option.
References
Arora NS, Ramanayake T, Ren YF, Romanos GE. Platelet-rich plasma: a literature review. Implant Dent. 2009;18(4):303–310.
Ayobami Akingboye A, Giddins S,Gamston P, Tucker A, Navsaria H; Kyriakides C. Application of Auto-logous Derived-Platelet Rich Plasma Gel in the Treatment of Chronic Wound Ulcer: Diabetic Foot Ulcer. JECT. 2010; 42:20–29.
Burnouf T, Goubran HA, Chen TM, Ou KL, El-Ekiaby M, Radosevic M. Blood-derived biomaterials and platelet growth factors in regenerative medicine. Blood Rev 2013; 27:77
Calderón Ibáñez T. La importancia de la cronicidad de las úlceras cutáneas; terapia alternativa con plasma rico en plaquetas. TFG, documento en internet. Disponible en: https://repositorio.unican.es/xmlui/ bitstream/handle/10902/11696/Calder%c3%b3n%20Ib%c3%a1%c3%b1ez%20Tamara.pdf?sequence=4&isAllowed=y
Castro G, Liceaga G, Arrioja A, Calleja JM, Espejel A. Guía Clínica basada en evidencia para el manejo del paciente diabético. Med Int Mex 2009; 25(6): 481-526.
Cervelli V et al. Tissue Regeneration in Loss of Substance on the Lower Limbs through Use of Platelet-Rich Plasma, Stem Cells from Adipose Tissue, and Hyaluronic Acid. Advances in Skin & Wound Care 2010; 23 (6):262-272.
Chícharo D, Rubio M, Damiá E, Carrillo J, Cuervo B, Peláez P. Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management. J FunctBiomater. 2018. 9: 1-20.
Dato Vidal MM. Plasma rico en plaquetas en el tratamiento de las heridas crónicas. Documento en internet. Disponible en: https://digitum.um.es/ digitum/bitstream/10201/56914/1/TFG%20Mar%C3%ADa%20de%20las%20Mercedes%20Dato%20Vidal-1.pdf.
Enríquez-Vega ME, Bobadilla-Flores NO, Rodríguez-Jiménez OA, Guerra-Márquez A, Carrasco-Nava L, Varela-Silva J. Plasma rico en plaquetas para el tratamiento de úlceras isquémicas del paciente diabético. Revista Mexicana de ANGIOLOGIA. 2012; 40 (2): 51-56.
Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg. 2004; 114(6)1502–1508.
Esperón Güimil JA, Loureiro Rodríguez MT, Antón Fuentes V, Rosendo Fernández JM, Pérez García I., Soldevilla-Agreda JJ. Variabilidad en el abordaje de las heridas crónicas: ¿qué opinan las enfermeras? Gerokomos.2014; 25(4):171-177.
Ficarelli E, Bernuzzi G, Tognetti E, et al. Treatment of chronic venous leg ulcers by platelet gel. Dermatol Ther. 2008; 21(1):13–17.
Frykberg RG, Driver VR, Carman D, Lucero B, Borris-Hale C, Carelyn P. Chronic Wounds Treated With a Physiologically Relevant Concentration of Platelet-rich Plasma Gel: A Prospective Case Series. Ostomy Wound Management 2010;56(6):36–44.
Gómez Sánchez ME, Azaña Defez JM, Escario Tra-vesedo E, Gómez Bajo GJ, López Villaescusa MT, Mar-tínez Martínez ML et al. Concentrado de plasma rico en plaquetas: revisión y uso en úlceras de larga evo-lución. Med Cutan Iber Lat Am 2015; 43 (2): 125-131.
Castro-Piedra SE, Arias-Varela KA. Actualización en plasma rico en plaquetas. Acta méd costarric 2019; 61 (4):142-151.
Kuffler D. Platelet Rich Plasma Promotes Axon Regeneration, Wound Healing and Pain Reduction: Fact or Fiction. Mol Neurobiol. 2015. 52:990-1014.
Lorenzo Hernández MP, Hernández Cano RM, Soria Suárez, MI. Heridas crónicas atendidas en un servicio de urgencias. Enfermería Global.2014; 35:23-31.
Marinel.lo Roura J, Verdú Soriano J (Coord.). Conferencia nacional de consenso sobre las úlceras de la extremidad inferior (C.O.N.U.E.I.). Documento de consenso 2018. 2ª ed. Madrid: Ergon; 2018.
Montón Echeverría J, Pérez Redondo S, Gómez Bajo GJ. Experiencia clínica en el empleo de factores de crecimiento autólogos obtenidos de plasma rico en plaquetas Resumen Abstract Clinical experience related to the use of autologous platelet rich plasma. Cir.plást. iberolatinoam 2007; .33 (3):155-162.
Marx R. Platelet rich plasma (PRP): What is PRP and what is not PRP. Dent. 2001. 10: 225-228.
Olmedo Gallardo AK, Miranda Muñoz GC, Layana Varas CM, Tettamanti Miranda D, Varas Diminich P. Plasma autólogo enriquecido en plaquetas vs debridaciones continuas en úlceras de miembros inferiores: estudio controlado en pacientes diabéticos e insuficientes venosos que acuden al Hospital Teodoro Maldonado Carbo en el período 2010. [Internet]. 2010. Disponible en: http://repositorio.ucsg.edu.ec/bitstream/3317/625/1/T-UCSG-PRE-MED-90.pdf [consulta: 20 jun 2020].
Roukis TS, Zgonis T, Tiernan B. Autologous platelet-rich plasma for wound and osseous healing: a review of the literature and commercially available products. Adv Ther. 2006;23(2):218–237.
Sussman C. Wound measurements. In: Sussman C, Bates-Jensen B (eds). Wound Care: A Collaborative Practice Manual for Physical Therapists and Nurses. Gaithersburg, MD: Aspen; 2001:120–141
Smith S, Roukis T. Bone and wound healing augmentation with plateletrich plasma. Clin Podiatr Med Surg. 2009; 26(4):559–588.)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.